Patient-reported outcomes such as fatigue, vitality and mental health improve substantially in the two years following hepatitis C cure for people with cirrhosis, but people with cirrhosis are less likely than others to experience rapid resolution of severe fatigue after successful hepatitis C treatment.

Quality of life can be severely impaired in people with chronic hepatitis C, especially in people with cirrhosis. Fatigue, insomnia, problems in physical functioning, depression, anxiety and mood disorders are reported by a substantial proportion of people with hepatitis C.

Fatigue was more likely to improve in younger people, in those without cirrhosis and in those with fewer co-morbidities. Depression, anxiety and insomnia were especially associated with a lack of improvement, as were type 2 diabetes, cirrhosis and co-infection with HIV.

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