DAAs Promising for HCV Patients With Hepatocellular Carcinoma

Of patients with hepatocellular carcinoma (HCC) and hepatitis C virus, about 75% can achieve virologic cure with direct-acting antiviral (DAA) drugs. In addition, more than 90% of HCC patients who have had a liver transplant can be cured of their HCV infection, according to a new study. Treatment of HCV in patients with HCC was uncommon before the advent of DAA medications. Moreover, the real-world effectiveness of DAA use in this population has remaine...

Hepatitis C mutations ‘outrun’ immune systems, lab study shows

Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development – Johns Hopkins Medicine Unlike its viral cousins hepatitis A and B, hepatitis C virus (HCV) has eluded the development of a vaccine and infected more than 170 million people worldwide. Now, researchers at Johns Hopkins Medicine report that a novel laboratory tool that lets them find virus mutations faster and more efficiently than ever before has ident

Increasing risk of cataract in HCV patients receiving anti-HCV therapy: A nationwide cohort study

Do you have cataracts? Did you ever take interferon? Hmmmm!!! Hepatitis C virus (HCV) infection is associated with increased systemic oxidative stress, which leads to cardiovascular events, diabetes, and chronic kidney disease. Similarly, cataract is also associated with increased oxidative stress. The association between HCV infection and increased risk of cataract remains unclear. In this study, we observed a positive association between pegylated in

Coverage Denials Eyed in HCV Rx Nonstarts

From the "Tell me something I don't already know department"! Coverage denials by payors are the main factor in a dramatic rise in failure to start hepatitis C drug treatment over the past three years, according to new data released March 8 by Trio Health, which has collected real-world evidence on 15,000 HCV patients since the launch of the direct-acting antiviral agents (DAAs) in 2014. As of 2016, more than one-third of patients prescribed DAA treatm

Hepatitis C Virus and the Dwindling of Research Funding

Curing the preponderance of patients treated for hepatitis C virus (HCV) is one of medicine’s most notable milestones, but research in this area appears to be grinding to a halt, according to a commentary in the first 2017 issue of Hepatology. With HCV dominating the subspecialty of hepatology for the past 25 years, some scientists believe that research should turn its attention and monetary resources to more urgent needs. Other experts disagree ...

Developing HCV Vaccine May Be Possible by Exposing Virus to Immune System Attack

Manipulating the major protein of the hepatitis C virus (HCV) allows the virus to be exposed in a way that the immune system can efficiently detect and attack it. This finding can help improve knowledge behind virus behavior and help in the development of a preventive vaccine for HCV infection. The results were recently published in the journal Hepatology in a study titled “The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neut

The Week in Review: March 3, 2017 – March 10, 2017

Friday, March 10, 2017 News Recap Seven Big Events in Six Days! A whirlwind of activity in three far-flung cities for HepCBC: 2 events in Vancouver, 3 in Banff, and 2 in Prince George!! March 1st – We had a busy info booth at Langara College's Nursing Dept. Health Fair, one in which challenges of the current opioid epidemic were featured. March 2nd – Our Vice President and Action Hepatitis Canada Steering Committee Representative, Delvin Gri...

Recent trip to the 2017 Liver Symposium with HepCBC at the Banff Springs Hotel, by Susan Malloch, R.N.

Considering I was trying to find a good excuse not to go to the HepC symposium it all turned to be a positive if not bittersweet experience for me. As you can imagine, the last year and a half has been heartbreaking without Allen. I guess I was afraid attending the symposium might reopen painful wounds I’ve been trying to heal. Anyway I mustered the courage up and off I went. My being a newbie on the board, Rosemary was an invaluable resource and a ...

Studies show hepatitis C test rates low despite effective new treatments

Note:  Although this study was done in the USA, the results hold true for Canada.  Why should people who feel stigmatized for having hepatitis C get tested only to be stared at down the nose by physicians who still put people with hep down, and also to find out that they can't afford to get treated!! It's a really lousy situation -- CD Despite a 2013 recommendation from the US Preventive Services Task force that all baby boomers be tested for hepatitis C

Persistent neuropsychiatric impairment in HCV patients despite clearance of the virus?!

This study from the Journal of Viral Hepatitis is very timely. We are hearing more and more from people who have been cured but are still suffering from brain fog One of the most disabling symptoms of hepatitis C virus (HCV) infection is chronic fatigue. While this is accepted for HCV polymerase chain reaction (PCR)-positive patients, a relationship between HCV infection and chronic fatigue is questioned after successful virus eradication. As fatigue is a