ACG Redefines Normal Range of ALT

What exactly is a normal value for alanine aminostransferase? That question is at the heart of a new guideline on the evaluation of abnormal liver chemistries issued by the American College of Gastroenterology (Am J Gastroenterol 2017;112:18-35). The guideline includes a new definition of normal ALT: a range of 19 to 25 IU/L for women and 29 to 33 IU/L for men. These values capture 95% of the healthy population. If the new definition is implemented wid

New, cost effective saliva test that diagnoses liver disease

Hepatitis E virus (HEV) causes liver disease that infects an estimated 20 million people worldwide each year and kills more than 56,000. New York: Scientists have developed an easier, cost effective 'oral fluid' test that uses saliva to diagnose liver disease and may eventually help develop its treatment. Hepatitis E virus (HEV) causes liver disease that infects an estimated 20 million people worldwide each year and kills more than 56,000. "HEV isn'

Quest Launches New Hepatitis C Virus Test Capabilities for Recently FDA-approved Antiviral Therapies

Apr 14, 2016 MADISON, N.J., April 14, 2016 /PRNewswire/ -- Quest Diagnostics (NYSE: DGX), the world's leading provider of diagnostic information services, today announced that it has expanded its chronic hepatitis C virus (HCV) test services to include new capabilities to help physicians identify or predict resistance to several HCV therapies, including the recently FDA-approved Zepatier™, from Merck, and Daklinza™, from Bristol-Myers Squibb. T...


AST to Platelet Ratio Index (APRI)   APRI above 1.5 can indicate advanced HCV liver damage. WARNING:  Do NOT use APRI alone as its accuracy rate is not sufficient to do so; experts recommend using a combination of two or  all three of the non-invasive liver tests (APRI, FibroSure/FibroTest, or FibroScan). Using the results of APRI, a non-invasive test, one can very roughly determine whether one has a high risk of having advanced live


FibroScan Alternative to Biopsy   Echosens™ Machine FIBROSCAN (also known as transient elastography, a technology developed by Echosens™ of Paris, France) poses the greatest competition to biopsy as it is non-invasive, less expensive, and (arguably) equally accurate in measuring degree of liver inflammation and fibrosis, particularly in the higher end of the Metavir scale (Stages 3 and 4).   Below you will find a Co

U.S.: FDA approves expanded use of Roche hepatitis C virus RNA test as aid in diagnosis

Test speeds treatment decisions, contributes to better patient careINDIANAPOLIS, March 21, 2016 /PRNewswire/ -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that it has received approval from the U.S. Food and Drug Administration (FDA) for its hepatitis C virus (HCV) quantitative RNA test to be used as an aid in the diagnosis of HCV infection for certain patient populations. Results from the COBAS AmpliPrep/COBAS TaqMan HCV Test, v2.0 can now be used