The Week in Review: Oct 26 – Nov 2, 2018

Friday, Nov 2, 2018 News Recap: Report on the Pacific AIDS Network (PAN) 2018 Fall Conference in Kelowna The Pacific AIDS Network held its annual Fall Conference and AGM October 30-31 in Kelowna. HepCBC attended this year for the first time as a Full Member, due to changes in the PAN Constitution and Bylaws. New Bylaws included: PAN no longer requires its hepatitis C organizational members to offer HIV-related services. Aging and Viral Hepatitis ...

Potential markers identified for early detection and prevention of liver cancer

Liver cancer is the second leading cause of cancer-related mortality worldwide, claiming 700,000 lives each year. Most cases are discovered too late for a cure—but now a study offers hope of early detection, and targets for new treatments. Published in Frontiers in Cell and Developmental Biology, the results show a dramatic increase in expression of sugar-burning 'glycolytic' enzymes in precancerous cirrhotic livers. This increase is associated with a sign

Alcoholic liver disease replaces hepatitis C infection as the leading cause of liver transplantation in patients without hepatocellular carcinoma in the USA

EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER -- 11 April 2018, Paris, France: Two independent studies have today reported that alcoholic liver disease has now replaced hepatitis C virus (HCV) infection as the leading cause of liver transplantation in the USA in patients without HCC. Non-alcoholic steatohepatitis (NASH) is also on the increase, now ranking second as a cause of liver transplantation due to chronic liver disease. Chronic HCV infection

The Week in Review: September 29 – October 6, 2017

Friday, October 6, 2017 News Recap: Liver Cancer Two studies on liver cancer in the news last week highlighted the global prevalence and causes of this terrible disease.  The first showed a direct correlation between excess weight and cancer occurrence (including liver cancer) – Cancers linked to excess weight make up 40% of all US diagnoses, study finds, while the second focussed on the global incidence of primary liver cancer. Hepatitis B virus wa...

Liver cancer remains a leading cause of cancer-related mortality worldwide

Primary liver cancer incidence increased by 75% between 1990 and 2015, and the disease remains one of the leading causes of cancer death in the world, according to a report from the Global Burden of Diseases Study 2015. Further, hepatitis B virus was the leading cause of new cases of liver cancer in 2015, the research showed. The highest rates of liver cancer incidence, disability-adjusted life-years and mortality occurred in East Asia. Japan had 75% o

DAAs Promising for HCV Patients With Hepatocellular Carcinoma

Of patients with hepatocellular carcinoma (HCC) and hepatitis C virus, about 75% can achieve virologic cure with direct-acting antiviral (DAA) drugs. In addition, more than 90% of HCC patients who have had a liver transplant can be cured of their HCV infection, according to a new study. Treatment of HCV in patients with HCC was uncommon before the advent of DAA medications. Moreover, the real-world effectiveness of DAA use in this population has remaine...

Effect of Sorafenib on Overall Survival Dependent on Viral Status

The effect of sorafenib on overall survival may depend on the hepatitis status of patients with advanced hepatocellular carcinoma (HCC), according to a study published in the Journal of Clinical Oncology. Findings from the Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) trial led to sorafenib becoming the standard of care for patients with advanced unresectable HCC. Patients who were both hepatitis B virus (HBV) negative and h

Bayer’s Regorafenib Significantly Improves Overall Survival in Patients with Unresectable Liver Cancer

Initial results from Phase III trial RESORCE to be presented as Late-Breaking Abstract in oral abstract session at WCGC / Median overall survival was 10.6 months for patients treated with regorafenib plus best supportive care versus 7.8 months in the group treated with placebo plus best supportive care. BERLIN, Germany I June 28, 2016 I Bayer today announced results from the Phase III RESORCE trial investigating its oncology compound regorafenib in patien

Liver Cancer Meeting – Link to Slideshows

Liver Cancer rates and deaths are rising all over the world; much of this increase is due to hepatitis C. Three of us from HepCBC attended a Liver Cancer (hepatocellular carcinoma or HCC) conference on Feb. 11th in Toronto, sponsored by the Canadian Assn. for the Study of the Liver (CASL). There will be an article summarizing the most interesting findings in the hepc.bull newsletter soon. Meanwhile, here is a link to the Powerpoint slides:http://www.hepato

HCV+ Baby Boomers with HCC increasing demand for Liver Transplant; may force changes in treatment plans

The December, 2012 issue of the journal Liver Transplantation discusses the rapidly-increasing demand for liver transplant among HCV+ Americans born between 1941 and 1960. 4% of this birth cohort is HCV+, compared to 1% for the US population as a whole. As this HCV+ population ages, the dangers of advanced cirrhosis and hepatocellular carcinoma (HCC) increase dramatically. 41% of those on the liver transplant list are HCV+, and of these the number who also