The Week in Review: June 15 – June 22, 2018

Friday, June 22, 2018 News Recap: Canada: All Kids Should Have a Hepatitis B Shot. Clinicians and researchers attending an international conference say all Canadian children should be vaccinated against hepatitis B starting at birth to prevent the development of potentially deadly liver disease later in life, a policy recommended by the World Health Organization. Currently, most provinces and territories immunize children against the liver-destroyin...

Researchers find a promising new approach for treating liver cirrhosis

A study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. Increased pressure in the veins leading to the liver, known

The Week in Review: October 13 – October 20, 2017

Friday, October 20, 2017 News Recap: Disease Management: Women: Hepatitis C in pregnancy: screening, treatment, and management. Hepatitis C (HCV) during pregnancy is associated with serious, adverse outcomes. Infants born to women with HCV are more likely to experience fetal growth restriction and low birth weight. For women, chronic HCV is associated with progressive liver damage and, during pregnancy, can be transmitted from the mother to the fe...

SVR reduces hepatic venous pressure gradient, portal hypertension persists

Sustained virologic response correlated with reduced hepatic venous pressure gradient in patients with HCV-associated cirrhosis, according to a recently published study. However, clinically significant portal hypertension continued to persist in most patients. “Development of [clinically significant portal hypertension] is a hallmark in the natural history of cirrhosis because it is associated with a higher risk of hepatic decompensation, and increased ri

Hepatitis C: Once the viral infection has healed, high-risk portal vein hypertension also diminishes

(Vienna, 15 June 2016) This inflammatory viral infection of the liver causes inflexible scar tissue  to form. This in turn impedes blood flow through the organ, with resulting hypertension in the portal vein. Portal hypertension is responsible for most of the lethal complications of liver cirrhosis. A research group led by hepatologists Mattias Mandorfer and Karin Kozbial of MedUni Vienna's Department of Gastroenterology and Hepatology have now demonstrat...