The Week in Review: June 15 – June 22, 2018

Friday, June 22, 2018 News Recap: Canada: All Kids Should Have a Hepatitis B Shot. Clinicians and researchers attending an international conference say all Canadian children should be vaccinated against hepatitis B starting at birth to prevent the development of potentially deadly liver disease later in life, a policy recommended by the World Health Organization. Currently, most provinces and territories immunize children against the liver-destroyin...

Researchers find a promising new approach for treating liver cirrhosis

A study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. Increased pressure in the veins leading to the liver, known

The Week in Review: June 8 – June 15, 2018

Friday, June 15, 2018 News Recap: Canada: Canada is facing a tsunami of liver disease and cancer: U of T expert – The Conversation with U of T's Dr. Morris Sherman. Deaths from liver cancer in Canada have doubled over the past 25 years. And to make matters worse, there’s an epidemic of liver cancer on the horizon if action isn’t taken soon. While less people are dying from most major cancers – such as breast cancer and lung cancer – liver cancer (...

Lungs from deceased donors with hepatitis C can be safely transplanted: researchers

Toronto doctors have successfully transplanted lungs from deceased donors with hepatitis C into patients in need of the life-saving organs, followed by treatment to prevent them from becoming infected with the potentially liver-destroying virus. Since October, surgeons at Toronto General Hospital have performed the transplants in 11 patients as part of a pilot study to evaluate the safety of using lungs from hepatitis C-infected donors — a previously unte

The Week in Review: June 1 – June 8, 2018

Friday, June 8, 2018 News Recap: Canada: New guidelines recommend hepatitis C screening be done for those born between 1945 and 1975. The Canadian Association for the Study of the Liver (CASL), a national group of health-care providers and researchers, published its guidelines on testing and treating hepatitis C in Monday's edition of the CMAJ. Canadians born between 1945 and 1975 – essentially the baby-boom generation – should be tested for the pot...

Findings could lead to treatment of hepatitis B

Researchers at the University of Delaware, working with colleagues at Indiana University, have gained new insights into the virus that causes hepatitis B -- a life-threatening and incurable infection that afflicts more than 250 million people worldwide. The discovery, which was published April 27 in the journal eLife, reveals previously unknown details about the capsid, or protein shell, that encloses the virus' genetic blueprint. Scientists believe th

The Week in Review: April 28 – May 11, 2018

Friday, May 11, 2018 News Recap: HBV: CADTH recommends that tenofovir alafenamide (TAF) be reimbursed for the treatment of chronic hepatitis B. The CADTH Canadian Drug Expert Committee (CDEC) recommends that tenofovir alafenamide (TAF) be reimbursed for the treatment of chronic hepatitis B in adults with compensated liver disease, if the following condition is met: CONDITION: The drug plan cost of TAF should not exceed that of the lowest-cost prepar...

This Common Viral Disease Has Plagued Humanity Thousands of Years Longer Than We Thought

Evidence of Hepatitis B has been found in human DNA dating back to the Bronze Age, around 4,500 years ago. We now have proof that it infected humans broadly across Eurasia for millennia, pushing back the earliest evidence we have by thousands of years. Previously, the earliest evidence of Hepatitis B was just 450 years old - and its discovery in a mummified medieval Italian child was only announced earlier this year. A team led by geneticist Eske Wille

The Week in Review: February 9 – February 16, 2018

Friday, February 16, 2018 News Recap: HCV & Heart Disease: Evolving Recognition of Chronic Hepatitis C Infection as a Modifiable Risk Factor for CVD. This article examines the evidence for clinical and subclinical cardiovascular diseases in chronic hepatitis c infection, as well as the effect of treatment on cardiovascular outcomes. News from Around the World: NZ: Thousands of Hepatitis C sufferers unaware a cure is within reach. A Hepatitis...

Study reveals the liver’s ‘weak spot’ for hepatitis B virus replication

In a surprising discovery, researchers from the Singapore Immunology Network (SIgN), A*STAR, have found that the liver is the main site of hepatitis B (HBV) replication—not only because it contains material that helps the virus proliferate, but also because most other tissues of the body contain proteins that actively repress HBV replication. "We've been working on this project for a number of years because HBV is very prevalent in Asia," says Ee Chee Ren