B.C. developed hepatitis C screening test personalizes treatment for patients

Scientists in Vancouver have developed a new screening tool that reveals the genetic signature of an individual’s hepatitis C virus so that doctors can customize their treatment. The tool, funded by Genome B.C. and devised by researchers at the B.C. Centre for Excellence in HIV/AIDS, could save money and lives, said Anita Howe, scientific lead for the hepatitis C program. “I would be able to tell you whether you are infected with a [virus] with resistant

Genetic Test Could Predict Transplant Success in People with Hep C, Cirrhosis

Although most people with hepatitis C virus can be cured, about 5 percent have more serious liver damage even after the virus is gone. A saliva test could identify genetic markers that indicate which people with hepatitis C and cirrhosis will benefit from certain treatments. Researchers say this test could help doctors predict outcomes after treating hepatitis C, and decrease the need for liver transplants. “Our findings further the move...

HCV Gene Mutations Present New Challenges for Vaccine Development

The hepatitis C virus (HCV) is known to mutate to avoid recognition by antibodies, neutralizing molecules of the host’s immune system. Surprisingly, researchers found that these mutations can occur in genes unrelated to the antibody binding site in the virus. The results are based on 113 HCV strains from 27 patients, and were reported in a study titled “Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by

Hepatitis C mutations ‘outrun’ immune systems, lab study shows

Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development – Johns Hopkins Medicine Unlike its viral cousins hepatitis A and B, hepatitis C virus (HCV) has eluded the development of a vaccine and infected more than 170 million people worldwide. Now, researchers at Johns Hopkins Medicine report that a novel laboratory tool that lets them find virus mutations faster and more efficiently than ever before has ident

Hepatitis C virus tricks liver cells to sabotage immune defenses

Virus induces liver cells to make molecules that inhibit production of a key immune signaling receptor. The virus that causes hepatitis C protects itself by blocking signals that call up immune defenses in liver cells, according to University of Washington researchers and colleagues reporting Nov. 14 in Nature Medicine. "The finding helps explain why many patients fail certain drug treatments, and should help develop more effective alternate treatm

A Common Virus Could Help Fight Liver Cancer And Hepatitis C

Reovirus, a common virus that causes mild cases of respiratory infection, mainly in children, could be harnessed as an immunotherapy to fight primary liver cancer and hepatitis C. Viruses cause around 20% of all human cancer. While only a handful are known to be tumour-promoting, this is a particular problem for liver cancer, where around three-quarters of cases are caused by either hepatitis C virus (HCV) or hepatitis B virus (HBV). These cause long-live

Cocrystal Announces Positive Interim Data from an Ongoing Phase 1 Study with CC-31244 for the Treatment of Chronic Hepatitis C Infection

ATLANTA, GA and BOTHELL, WA -- (Marketwired) -- 11/07/16 -- Cocrystal Pharma, Inc. (OTCQB: COCP), announced positive data from a randomized, double-blind Phase Ia/Ib study of CC-31244, a pan-genotypic, potent NS5B non-nucleoside inhibitor (NNI), for the treatment of chronic hepatitis C virus (HCV) infection. The study is designed to evaluate CC-31244's safety/tolerability and pharmacokinetics, including food effect and antiviral activity. The study includ

Two genes linked to increase in immunity to hepatitis C after childbirth, study shows

Alternative forms of two genes are associated with a boost in immunity to hepatitis C after childbirth, a study led by a Nationwide Children's Hospital physician-researcher shows. At three months postpartum, the number of viruses circulating in the blood declined sharply in most women who carried particular versions of IFNL3 and HLA-DPB1 genes. Mothers lacking these gene variants experienced little change in viral levels after delivery. The research is

Transplant experiment relies on hepatitis C-infected kidneys

WASHINGTON -- Some patients facing a years-long wait for a kidney transplant are jumping ahead in line thanks to a startling experiment: They're agreeing to an organ almost sure to infect them with hepatitis C. Knowingly transmitting a dangerous virus may sound drastic, but two leading transplant centres are betting the strategy will save lives, if new medications that promise to cure hepatitis C allow use of organs that today go to waste. Pilot studie

Scientists uncover why Hepatitis C virus vaccine has been difficult to make

Scripps Research Institute La Jolla, CA -- Oct. 24, 2016 -- Researchers have been trying for decades to develop a vaccine against the globally endemic hepatitis C virus (HCV). Now scientists at The Scripps Research Institute (TSRI) have discovered one reason why success has so far been elusive. Using a sophisticated array of techniques for mapping tiny molecular structures, the TSRI scientists analyzed a lab-made version of a key viral protein, which