New, cost effective saliva test that diagnoses liver disease

Hepatitis E virus (HEV) causes liver disease that infects an estimated 20 million people worldwide each year and kills more than 56,000. New York: Scientists have developed an easier, cost effective 'oral fluid' test that uses saliva to diagnose liver disease and may eventually help develop its treatment. Hepatitis E virus (HEV) causes liver disease that infects an estimated 20 million people worldwide each year and kills more than 56,000. "HEV isn'

Engineered liver tissue expands after transplant

Researchers at MIT, Rockefeller University, and Boston University have developed a new way to engineer liver tissue, by organizing tiny subunits that contain three types of cells embedded into a biodegradable tissue scaffold. Many diseases, including cirrhosis and hepatitis, can lead to liver failure. More than 17,000 Americans suffering from these diseases are now waiting for liver transplants, but significantly fewer livers are available. To help add

Transplanting kidneys with Hepatitis C saves patients’ lives, cures disease

"Just because the donor has hepatitis C, their kidney quality may not be impaired, especially if you can cure the virus. Because the disease exerts its effects very slowly, it’s possible that a young donor or someone in the early stages of the disease may have very few health problems that result from HCV, meaning those kidneys are high-quality." More than 97,000 people in the United States are currently awaiting kidney transplants—waits that can often ta...

Researchers identify how class of drugs blocks Hepatitis C virus replication

Findings reveal a difference between strains of HCV Chapel Hill, NC - Globally, an estimated 71 million people are living with chronic hepatitis C virus (HCV). Over decades of infection, chronic HCV infection results in progressive damage to the liver and an increased risk for end stage liver disease and liver cancer, making the virus the leading cause of liver-related deaths in the United States today. While effective combination therapies have re

On-the-spot hepatitis test being developed in Swansea

An on-the-spot test to diagnose three types of hepatitis is being developed. It would use a patient's saliva instead of blood and the test would be as simple and quick as a blood glucose sensor or a pregnancy test. Current screening for hepatitis A, B and C involves taking blood with results taking up to seven days. The two-year project is a joint venture between the UK and China with Swansea playing a key role through Swansea University's Centre fo

B.C. developed hepatitis C screening test personalizes treatment for patients

Scientists in Vancouver have developed a new screening tool that reveals the genetic signature of an individual’s hepatitis C virus so that doctors can customize their treatment. The tool, funded by Genome B.C. and devised by researchers at the B.C. Centre for Excellence in HIV/AIDS, could save money and lives, said Anita Howe, scientific lead for the hepatitis C program. “I would be able to tell you whether you are infected with a [virus] with resistant

Genetic Test Could Predict Transplant Success in People with Hep C, Cirrhosis

Although most people with hepatitis C virus can be cured, about 5 percent have more serious liver damage even after the virus is gone. A saliva test could identify genetic markers that indicate which people with hepatitis C and cirrhosis will benefit from certain treatments. Researchers say this test could help doctors predict outcomes after treating hepatitis C, and decrease the need for liver transplants. “Our findings further the move...

HCV Gene Mutations Present New Challenges for Vaccine Development

The hepatitis C virus (HCV) is known to mutate to avoid recognition by antibodies, neutralizing molecules of the host’s immune system. Surprisingly, researchers found that these mutations can occur in genes unrelated to the antibody binding site in the virus. The results are based on 113 HCV strains from 27 patients, and were reported in a study titled “Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by

Hepatitis C mutations ‘outrun’ immune systems, lab study shows

Study identifies mutations outside of traditional vaccine targets as barrier to vaccine development – Johns Hopkins Medicine Unlike its viral cousins hepatitis A and B, hepatitis C virus (HCV) has eluded the development of a vaccine and infected more than 170 million people worldwide. Now, researchers at Johns Hopkins Medicine report that a novel laboratory tool that lets them find virus mutations faster and more efficiently than ever before has ident

Hepatitis C virus tricks liver cells to sabotage immune defenses

Virus induces liver cells to make molecules that inhibit production of a key immune signaling receptor. The virus that causes hepatitis C protects itself by blocking signals that call up immune defenses in liver cells, according to University of Washington researchers and colleagues reporting Nov. 14 in Nature Medicine. "The finding helps explain why many patients fail certain drug treatments, and should help develop more effective alternate treatm